Memória Imunológica

UNIVERSIDADE FEDERAL DE GOIÁS
INSTITUTO DE PATOLOGIA TROPICAL E SAÚDE PÚBLICA
PROGRAMA DE PÓS-GRADUAÇAO EM MEDICINA TROPICAL E SAÚDE PÚBLICA
Disciplina: Memória Imunológica
Carga Horária: 45 horas
Total de créditos: 3
Professor responsável: Simone Gonçalves da Fonseca
Contato: (e-mail/telefone/sala): [email protected] / 3209-6111
Professores convidados:
EMENTA
O curso pretende abordar os mecanismos geradores da memória imunológica de
linfócitos T, mecanismos mantenedores de células T de memória imunológica e
mecanismos efetores da resposta imune de memória.
AVALIAÇÃO
A avaliação será feita pela apresentação de um artigo científico selecionado pelo
professor e pela participação nas discussões. Cada aluno apresentará um artigo
científico e essa apresentação valerá 10 pontos. E a participação do aluno nas
discussões durante o curso valerá 10 pontos.
Será feita a média aritmética dessas duas notas: 10+10/2=nota final
BIBLIOGRAFIA
Restifo NP, Gattinoni L. Lineage relationship of effector and memory T cells.
Curr Opin Immunol. 2013 Oct;25(5):556-63. doi: 10.1016/j.coi.2013.09.00
Farber DL, Yudanin NA, Restifo NP. Human memory T cells: generation,
compartmentalization and homeostasis. Nat Rev Immunol. 2014 Jan;14(1):24-35.
ehn D, Wherry EJ. Immune Memory and Exhaustion: Clinically Relevant Lessons
from the LCMV Model. Adv Exp Med Biol. 2015;850:137-52. doi:
10.1007/978-3-319-15774-0_10. PubMed PMID: 26324351.
Park CO, Kupper TS. The emerging role of resident memory T cells in protective
immunity and inflammatory disease. Nat Med. 2015 Jul;21(7):688-97. doi:
10.1038/nm.3883.
3: Youngblood B, Hale JS, Ahmed R. Memory CD8 T cell transcriptional plasticity.
F1000Prime Rep. 2015 Apr 1;7:38. doi: 10.12703/P7-38. eCollection 2015.
4: Hale JS, Ahmed R. Memory T follicular helper CD4 T cells. Front Immunol. 2015
Feb 2;6:16. doi: 10.3389/fimmu.2015.00016. eCollection 2015.
Halwani R, Doroudchi M, Yassine-Diab B, Janbazian L, Shi Y, Said EA, Haddad
EK, Sékaly RP. Generation and maintenance of human memory cells during viral
infection. Springer Semin Immunopathol. 2006 Nov;28(3):197-208. Epub 2006 Sep 12.
Tanel A, Fonseca SG, Yassine-Diab B, Bordi R, Zeidan J, Shi Y, Benne C, Sékaly
RP. Cellular and molecular mechanisms of memory T-cell survival. Expert Rev
Vaccines. 2009 Mar;8(3):299-312. doi: 10.1586/14760584.8.3.299.
Murphy KM, Reiner SL. The lineage decisions of helper T cells. Nat Rev
Immunol. 2002 Dec;2(12):933-44. Review. PubMed PMID: 12461566.
Intlekofer AM, Wherry EJ, Reiner SL. Not-so-great expectations: re-assessing
the essence of T-cell memory. Immunol Rev. 2006 Jun;211:203-13. Review.
Opata MM, Stephens R. Early Decision: Effector and Effector Memory T Cell
Differentiation in Chronic Infection. Curr Immunol Rev. 2013 Aug;9(3):190-206.
PubMed PMID: 24790593; PubMed Central PMCID: PMC4000274.
Mahnke YD, Brodie TM, Sallusto F, Roederer M, Lugli E. The who's who of T-cell
differentiation: human memory T-cell subsets. Eur J Immunol. 2013
Nov;43(11):2797-809. doi: 10.1002/eji.201343751. Epub 2013 Oct 30. Review. PubMed
PMID: 24258910.
Zielinski CE, Corti D, Mele F, Pinto D, Lanzavecchia A, Sallusto F. Dissecting
the human immunologic memory for pathogens. Immunol Rev. 2011 Mar;240(1):40-51.
doi: 10.1111/j.1600-065X.2010.01000.x. Review. PubMed PMID: 21349085.
Sallusto F, Geginat J, Lanzavecchia A. Central memory and effector memory T
cell subsets: function, generation, and maintenance. Annu Rev Immunol.
2004;22:745-63. Review. PubMed PMID: 15032595.
Lanzavecchia A, Sallusto F. From synapses to immunological memory: the role of
sustained T cell stimulation. Curr Opin Immunol. 2000 Feb;12(1):92-8. Review.
PubMed PMID: 10679412.
Lanzavecchia A, Sallusto F. Dynamics of T lymphocyte responses: intermediates,
effectors, and memory cells. Science. 2000 Oct 6;290(5489):92-7. Review. PubMed
PMID: 11021806.
Sallusto F, Lanzavecchia A. Understanding dendritic cell and T-lymphocyte
traffic through the analysis of chemokine receptor expression. Immunol Rev. 2000
Oct;177:134-40. Review. PubMed PMID: 11138771.
Lanzavecchia A, Sallusto F. Antigen decoding by T lymphocytes: from synapses
to fate determination. Nat Immunol. 2001 Jun;2(6):487-92. Review. PubMed PMID:
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9: Sallusto F, Lanzavecchia A. Exploring pathways for memory T cell generation. J
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Geginat J, Campagnaro S, Sallusto F, Lanzavecchia A. TCR-independent
proliferation and differentiation of human CD4+ T cell subsets induced by
cytokines. Adv Exp Med Biol. 2002;512:107-12. Review. PubMed PMID: 12405193.
Lanzavecchia A, Sallusto F. Progressive differentiation and selection of the
fittest in the immune response. Nat Rev Immunol. 2002 Dec;2(12):982-7. Review.
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Geginat J, Sallusto F, Lanzavecchia A. Cytokine-driven proliferation and
differentiation of human naïve, central memory and effector memory CD4+ T cells.
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Lanzavecchia A, Sallusto F. Understanding the generation and function of
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Data
25/01/2016
CRONOGRAMA E CONTEÚDO PROGRAMÁTICO
Assunto
Docente
Histórico das células de memória
Simone
Discussão de artigos
Simone
Mecanismos geradores de células T de memória
Simone
Discussão de artigos
Simone
Caracterização fenotípica e funcional
Simone
Discussão de artigos
Simone
9:00-12:00
25/01/2016
13:00-18:00
26/01/2016
9:00-12:00
26/01/2016
13:00-18:00
27/01/2016
9:00-12:00
27/01/2016
13:00-18:00
29/01/2016
Mecanismo de sobrevivência
9:00-12:00
29/01/2016
Discussão de artigos
Simone
Mecanismos efetores
Simone
Discussão de artigos
Simone
13:00-18:00
1/02/2016
9:00-12:00
1/02/2016
13:00-18:00
2/02/2016
13:00-18:00
Avaliação