Gram-positive bacteria specific properties of silybin derived from

Silibinina inibe bactérias Gram positivas, mas não possui efeito contra as Gram negativas e
fungos
Gram-positive bacteria specific properties of silybin derived
from Silybum marianum.
Lee DG, Kim HK, Park Y, Park SC, Woo ER, Jeong HG, Hahm KS.
Arch Pharm Res. 2003 Aug;26(8):597-600.
Source
Research Center for Proteineous Materials, Chosun University, Korea.
Abstract
Silybin has a potent antibacterial activity, more potent than silymarin II, against gram-positive
bacteria without hemolytic activity, whereas it has no antimicrobial activity against gramnegative bacteria or fungi. The mode of action of silybin against the gram-positive bacterial cell
was examined by investigating the change in plasma membrane dynamics of bacterial cells
using 1,6-diphenyl-1,3,5-hextriene (DPH) as a membrane probe and by assessing the inhibition
of macromolecular synthesis using radiolabeled incorporation assay. The results showed that
silybin inhibited RNA and protein synthesis on gram-positive bacteria.
PMID:12967193