[The regulation of B-lymphocyte activity by the Epstein

01/12/11
Lupus eritematoso sistêmico, esclerose sistêmica, artrite reumatóide e espondilite
anquilosante e o Vírus Epstein Barr
No Lupus eritematoso sistêmico, esclerose sistêmica e artrite reumatóide o EBV provoca em %
diferentes em cada doença autoimune uma deficiência da atividade supressora do linfócito T
sobre o linfócito B . Tal fato não ocorre na espondilite anquilosante. Jose de Felippe JUnior
[The regulation of B-lymphocyte activity by the Epstein-Barr
virus in ankylosing spondylarthritis].
[Article in Bulgarian]
Peĭcheva V, Kan A, Amor B.
Vutr Boles. 1990;29(5):88-91.
Abstract
Former studies of the authors have indicated a deficit of the suppressor function of the T-lymphocytes on
the activity of the B-lymphocytes by the Epstein-Barr Virus (EBV) in systemic autoimmune diseases: in
60% of the patients with rheumatoid arthritis, 50% of the patients with systemic sclerosis and 80% of the
patients with systemic lupus erythematodes. Deficit of the specific cytotoxic function of the EBV in
ankylosing spondylarthritis has been described. A study was carried out on 13 patients with ankylosing
spondylarthritis and 13 healthy controls. All were immunized with EBV. Cultures were made
experimentally. The secretion of IgM and IgG in the supernatant of the cultures was tested by ELISA. The
T-suppression function of the specific T-lymphocytes of the EBV is not decreased in ankylosing
spondylarthritis.
PMID:
1964317